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Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A

Abstract:

The mature retrovirus capsid consists of a variably curved lattice of capsid protein (CA) hexamers and pentamers. High-resolution structures of the curved assembly, or in complex with host factors, have not been available. By devising cryo-EM methodologies for exceedingly flexible and pleomorphic assemblies, we have determined cryo-EM structures of apo-CA hexamers and in complex with cyclophilin A (CypA) at near-atomic resolutions. The CA hexamers are intrinsically curved, flexible and asymme...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41594-020-0467-8

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
ORCID:
0000-0001-7268-0306
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Role:
Author
ORCID:
0000-0002-2842-0360
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Role:
Author
ORCID:
0000-0003-0330-1581
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Name:
Biotechnology and Biological Sciences Research Council
Grant:
BB/S003339/1
Publisher:
Springer Nature
Journal:
Nature Structural and Molecular Biology More from this journal
Volume:
27
Issue:
9
Pages:
855-862
Publication date:
2020-08-03
Acceptance date:
2020-06-19
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Pmid:
32747784

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