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A Monte Carlo approach for assessing the specificity of protein oligomers observed in nano-electrospray mass spectra

Abstract:

Nano-electrospray mass spectrometry is an emerging approach for studying the architecture and dynamics of complex oligomeric proteins. The analysis of such species can, however, be hindered by 'non-specific' protein-protein associations which arise as a result of the electrospray method. To understand the formation of specific versus non-specific protein oligomers detected by mass spectrometry we have developed a simple and rapid computational approach. This Monte Carlo algorithm characterize...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.ijms.2009.03.006

Authors


Ruotolo, BT More by this author
More by this author
Department:
Exeter College
Publisher:
Elsevier Publisher's website
Journal:
International Journal of Mass Spectrometry Journal website
Volume:
283
Issue:
1-3
Pages:
169-177
Publication date:
2009-06-01
DOI:
ISSN:
1387-3806
Pubs id:
pubs:59401
URN:
uri:8a2ac9d1-e209-4d32-b8a1-db9e1b743fd0
UUID:
uuid:8a2ac9d1-e209-4d32-b8a1-db9e1b743fd0
Local pid:
pubs:59401
Keywords:

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