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A Monte Carlo approach for assessing the specificity of protein oligomers observed in nano-electrospray mass spectra

Abstract:

Nano-electrospray mass spectrometry is an emerging approach for studying the architecture and dynamics of complex oligomeric proteins. The analysis of such species can, however, be hindered by 'non-specific' protein-protein associations which arise as a result of the electrospray method. To understand the formation of specific versus non-specific protein oligomers detected by mass spectrometry we have developed a simple and rapid computational approach. This Monte Carlo algorithm characterize...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
  • (Accepted manuscript, pdf, 1.2MB)
Publisher copy:
10.1016/j.ijms.2009.03.006

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Institution:
University of Oxford
Oxford college:
Exeter College
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
International Journal of Mass Spectrometry Journal website
Volume:
283
Issue:
1-3
Pages:
169-177
Publication date:
2009-06-01
DOI:
ISSN:
1387-3806
Source identifiers:
59401
Keywords:
Pubs id:
pubs:59401
UUID:
uuid:8a2ac9d1-e209-4d32-b8a1-db9e1b743fd0
Local pid:
pubs:59401
Deposit date:
2017-01-25

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