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Chemoenzymatic synthesis of a phosphorylated glycoprotein

Abstract:

The majority of lysosomal enzymes are targeted to the lysosome by post-translational tagging with N-glycans terminating in mannose-6-phosphate (M6P) residues. Some current enzyme replacement therapies (ERTs) for lysosomal storage disorders are limited in their efficacy by the extent to which the recombinant enzymes bear the M6P-terminated glycans required for effective trafficking. Chemical synthesis was combined with endo-β-N-acetylglucosaminidase (ENGase) catalysis to allow the convergent s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/anie.201600817

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Publisher:
Wiley Publisher's website
Journal:
Angewandte Chemie Journal website
Volume:
16
Issue:
11
Pages:
5058–5061
Publication date:
2016-03-11
DOI:
ISSN:
1433-7851 and 1521-3773
Pmid:
26971709
Language:
English
Keywords:
Pubs id:
pubs:611758
UUID:
uuid:8a250c30-d1fe-4686-b6dd-5f461eb21e22
Local pid:
pubs:611758
Deposit date:
2016-10-06

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