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Bone morphogenetic protein and Notch signalling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer.

Abstract:

The functional role of bone morphogenetic protein (BMP) signalling in colorectal cancer (CRC) is poorly defined, with contradictory results in cancer cell line models reflecting the inherent difficulties of assessing a signalling pathway that is context-dependent and subject to genetic constraints. By assessing the transcriptional response of a diploid human colonic epithelial cell line to BMP ligand stimulation, we generated a prognostic BMP signalling signature, which was applied to multipl...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/path.4891

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Publisher:
Wiley Publisher's website
Journal:
Journal of Pathology Journal website
Volume:
242
Issue:
2
Pages:
178-192
Publication date:
2017-05-01
Acceptance date:
2017-03-15
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
Language:
English
Keywords:
Pubs id:
pubs:686461
UUID:
uuid:8a207f9a-dbda-498f-8dce-91bf0b732ba3
Local pid:
pubs:686461
Deposit date:
2017-07-17

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