Determination of fetal RhD status by maternal plasma DNA analysis.

Journal article

The prenatal determination of fetal rhesus D (RhD) status is useful for the management of sensitized RhD-negative women. Conventional methods for prenatal RhD status determination involve invasive methods such as amniocentesis. The discovery of circulating cell-free fetal DNA in maternal plasma and serum opens up a new source of fetal genetic material for prenatal RhD status determination. Indeed, this possibility has recently been realized by three groups who demonstrated the presence of fet...

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Authors: Zhang, J; Fidler, C; Murphy, M; Chamberlain, P; Sargent, I

• Publication status: Published
• Journal: Annals of the New York Academy of Sciences
• Volume: 906
• Issue: 1
• Pages: 153-155
• Publication date: 2000-04-01
• DOI: 10.1111/j.1749-6632.2000.tb06606.x
• EISSN: 1749-6632
• ISSN: 0077-8923
• Language: English
• Keywords: Humans; Pregnancy; Polymerase Chain Reaction; Female; Base Sequence; Maternal-Fetal Exchange; Rh-Hr Blood-Group System; DNA Primers