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P667Impaired chronic hypoxic response in type 2 diabetic hearts is associated with inability to downregulate PPARa.

Abstract:

Cardiovascular disease is the leading cause of mortality in type 2 diabetic patients. Metabolic changes and abnormal hypoxia signalling in the diabetic heart are hypothesised to decrease recovery following a myocardial infarction. Therefore the aim of this study was to investigate the cardiac metabolic adaptation to physiological hypoxia in diabetic rats. Type 2 diabetes was generated in rats using a high fat diet and low dose streptozotocin. Both control and diabetic rats were housed in hypo...

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Publication status:
Published

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Publisher copy:
10.1093/cvr/cvu098.92

Authors


Le Page, L More by this author
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Journal:
Cardiovascular research
Volume:
103 Suppl 1
Issue:
suppl 1
Pages:
S122
Publication date:
2014-07-05
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
URN:
uuid:8a188c37-9b01-435c-bf64-72f237b2d6a1
Source identifiers:
475916
Local pid:
pubs:475916
Language:
English

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