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Journal article

T cell cross-reactivity and conformational changes during TCR engagement.

Abstract:

All thymically selected T cells are inherently cross-reactive, yet many data indicate a fine specificity in antigen recognition, which enables virus escape from immune control by mutation in infections such as the human immunodeficiency virus (HIV). To address this paradox, we analyzed the fine specificity of T cells recognizing a human histocompatibility leukocyte antigen (HLA)-A2-restricted, strongly immunodominant, HIV gag epitope (SLFNTVATL). The majority of 171 variant peptides tested bo...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20041251

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Journal:
Journal of experimental medicine
Volume:
200
Issue:
11
Pages:
1455-1466
Publication date:
2004-12-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Source identifiers:
14122
Language:
English
Keywords:
Pubs id:
pubs:14122
UUID:
uuid:8a0ff03d-2aae-4b0a-9964-f12ea38d5f59
Local pid:
pubs:14122
Deposit date:
2012-12-19

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