Inferring parameters of mutation, selection and demography from patterns of synonymous site evolution in Drosophila.

Journal article

Selection acting on codon usage can cause patterns of synonymous evolution to deviate considerably from those expected under neutrality. To investigate the quantitative relationship between parameters of mutation, selection, and demography, and patterns of synonymous site divergence, we have developed a novel combination of population genetic models and likelihood methods of phylogenetic sequence analysis. Comparing 50 orthologous gene pairs from Drosophila melanogaster and D. virilis and 27 ...

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Authors: Mcvean, G; Vieira, J

• Journal: Genetics
• Volume: 157
• Issue: 1
• Pages: 245-257
• Publication date: 2001-01-01
• EISSN: 1943-2631
• ISSN: 0016-6731
• Language: English
• Keywords: Genes, Insect; Drosophila melanogaster; Gene Frequency; Evolution, Molecular; Genetics, Population; Models, Genetic; Likelihood Functions; Codon; Selection, Genetic; Base Composition; Animals; Drosophila; Mutation