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Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein.

Abstract:

The cDNA for one of the receptors for human tumor necrosis factor (TNF) has been isolated. This cDNA encodes a protein of 455 amino acids that is divided into an extracellular domain of 171 residues and a cytoplasmic domain of 221 residues. The extracellular domain has been engineered for expression in mammalian cells, and this recombinant derivative binds TNF alpha with high affinity and inhibits its cytotoxic activity in vitro. The TNF receptor exhibits similarity with a family of cell surf...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.87.19.7380

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
87
Issue:
19
Pages:
7380-7384
Publication date:
1990-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:8a00206b-7107-45bb-961b-88b15c474ae1
Source identifiers:
481747
Local pid:
pubs:481747

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