Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

Journal article

ICAM-1 is a cell surface glycoprotein originally defined by a monoclonal antibody (MAb) that inhibits phorbol ester-stimulated leukocyte aggregation. Staining of frozen sections and immunofluorescence flow cytometry showed intercellular adhesion molecule-1 (ICAM-1) is expressed on non-hematopoietic cells such as vascular endothelial cells, thymic epithelial cells, certain other epithelial cells, and fibroblasts, and on hematopoietic cells such as tissue macrophages, mitogen-stimulated T lymph...

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Authors: Dustin, M; Rothlein, R; Bhan, A; Dinarello, C; Springer, T

• Journal: Journal of Immunology
• Volume: 137
• Issue: 1
• Pages: 245-254
• Publication date: 1986-07-01
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Animals; Flow Cytometry; Dose-Response Relationship, Immunologic; Interleukin-1; Humans; Mice; Interferon-gamma; Kinetics; Tissue Distribution; Protein Biosynthesis; Fluorescent Antibody Technique; RNA, Messenger; Immunity, Innate; Cell Adhesion; Antigens, Surface; Cell Adhesion Molecules