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Journal article

Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children.

Abstract:

The highly sensitive quantitation of virus-specific CD8(+) T cells using major histocompatibility complex-peptide tetramer assays has revealed higher levels of cytotoxic T lymphocytes (CTLs) in acute and chronic virus infections than were recognized previously. However, studies in lymphocytic choriomeningitis virus infection have shown that tetramer assays may include measurement of a substantial number of tetramer-binding cells that are functionally inert. Such phenotypically silent CTLs, wh...

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Publication status:
Published

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Publisher copy:
10.1084/jem.192.12.1819

Authors


Goulder, PJ More by this author
Brander, C More by this author
Altfeld, M More by this author
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Journal:
The Journal of experimental medicine
Volume:
192
Issue:
12
Pages:
1819-1832
Publication date:
2000-12-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:89f88375-bb7a-4da7-8cb4-c0424280dff6
Source identifiers:
3515
Local pid:
pubs:3515

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