- Abstract:
-
The highly sensitive quantitation of virus-specific CD8(+) T cells using major histocompatibility complex-peptide tetramer assays has revealed higher levels of cytotoxic T lymphocytes (CTLs) in acute and chronic virus infections than were recognized previously. However, studies in lymphocytic choriomeningitis virus infection have shown that tetramer assays may include measurement of a substantial number of tetramer-binding cells that are functionally inert. Such phenotypically silent CTLs, wh...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1084/jem.192.12.1819
-
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- Journal:
- The Journal of experimental medicine
- Volume:
- 192
- Issue:
- 12
- Pages:
- 1819-1832
- Publication date:
- 2000-12-05
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
- URN:
-
uuid:89f88375-bb7a-4da7-8cb4-c0424280dff6
- Source identifiers:
-
3515
- Local pid:
- pubs:3515
- Language:
- English
- Keywords:
- Copyright date:
- 2000
Journal article
Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children.
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