Cytokine (TNF alpha, LT alpha and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: differential effects on production and allele frequencies.

Journal article

The influence of biallelic polymorphisms in the tumour necrosis factor-alpha (TNF alpha), lymphotoxin-alpha (LT alpha) and interleukin-10 (IL-10) genes on stimulated TNF alpha and IL-10 production was studied in ulcerative colitis (UC) patients, Crohn's disease (CD) patients and in healthy controls. A polymerase chain reaction sequence-specific primer (PCR-SSP) system was developed to type nine biallelic polymorphisms, three in each of the TNF alpha, LT alpha and IL-10 genes. Production of th...

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Authors: Koss, K; Satsangi, J; Fanning, G; Welsh, K; Jewell, D

• Publication status: Published
• Journal: Genes and immunity
• Volume: 1
• Issue: 3
• Pages: 185-190
• Publication date: 2000-02-01
• DOI: 10.1038/sj.gene.6363657
• EISSN: 1476-5470
• ISSN: 1466-4879
• Language: English
• Keywords: Cytokines; Case-Control Studies; Colitis, Ulcerative; Adolescent; Smoking; Polymorphism, Genetic; Alleles; Gene Frequency; Crohn Disease; Humans; Polymerase Chain Reaction; Adult; Female; Male; Tumor Necrosis Factor-alpha; Lymphotoxin-alpha; Interleukin-10; Aged; Middle Aged