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KIR3DL2 Binds to HLA-B27 Dimers and Free H Chains More Strongly than Other HLA Class I and Promotes the Expansion of T Cells in Ankylosing Spondylitis.

Abstract:

The human leukocyte Ag HLA-B27 (B27) is strongly associated with the spondyloarthritides. B27 can be expressed at the cell surface of APC as both classical [beta]2-microglobulin-associated B27 and B27 free H chain forms (FHC), including disulfide-bonded H chain homodimers (termed B272). B27 FHC forms, but not classical B27, bind to KIR3DL2. HLA-A3, which is not associated with spondyloarthritis (SpA), is also a ligand for KIR3DL2. In this study, we show that B272 and B27 FHC bind more strongl...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4049/jimmunol.1202926

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
More from this funder
Name:
Belmont Trust
Funding agency for:
Bowness, P
More from this funder
Name:
Japan Society for the Promotion of Science
Funding agency for:
Hatano, H
More from this funder
Name:
Arthritis Research U.K.
Funding agency for:
Shaw, J
Rysnik, O
Kollnberger, S
More from this funder
Name:
Biomedical Research Centre, Oxford National Institute for Health Research
Funding agency for:
Ridley, A
Bowness, P
More from this funder
Name:
Consejo Nacional de Ciencia y Tecnologia Mexico
Funding agency for:
Wong-Baeza, I
Publisher:
American Association of Immunologists, Inc.
Journal:
Journal of Immunology More from this journal
Volume:
190
Issue:
7
Pages:
3216-3224
Publication date:
2013-02-25
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Language:
English
Keywords:
Pubs id:
pubs:390787
UUID:
uuid:89ed8d73-9065-4e8b-96a8-1c19037b94f9
Local pid:
pubs:390787
Source identifiers:
390787
Deposit date:
2013-09-26

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