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Skeletal muscle alkaline Pi pool is decreased in overweight-to-obese sedentary subjects and relates to mitochondrial capacity and phosphodiester content.

Abstract:

Defects in skeletal muscle energy metabolism are indicative of systemic disorders such as obesity or type 2 diabetes. Phosphorus magnetic resonance spectroscopy ((31)P-MRS), in particularly dynamic (31)P-MRS, provides a powerful tool for the non-invasive investigation of muscular oxidative metabolism. The increase in spectral and temporal resolution of (31)P-MRS at ultra high fields (i.e., 7T) uncovers new potential for previously implemented techniques, e.g., saturation transfer (ST) or high...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/srep20087

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Chmelík, M More by this author
Ukropcová, B More by this author
Heckmann, T More by this author
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Funding agency for:
Valkovič, L
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Grant:
#15363; #15455; #16133
European Foundation for the Study of Diabetes More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific reports Journal website
Volume:
6
Pages:
20087
Publication date:
2016
DOI:
EISSN:
2045-2322
URN:
uuid:89e86e56-3a7b-4041-8f86-9bce0fe67d81
Source identifiers:
598981
Local pid:
pubs:598981
Language:
English

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