Journal article
This is a platform alteration: a trial management perspective on the operational aspects of adaptive and platform and umbrella protocols
- Abstract:
-
BACKGROUND: There are limited research and literature on the trial management challenges encountered in running adaptive platform trials. This trial design allows both (1) the seamless addition of new research comparisons when compelling clinical and scientific research questions emerge, and (2) early stopping of accrual to individual comparisons that do not show sufficient activity without affecting other active comparisons. Adaptive platform design trials also offer many...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- Trials Journal website
- Volume:
- 20
- Issue:
- 1
- Article number:
- 264
- Publication date:
- 2019-05-09
- Acceptance date:
- 2019-01-09
- DOI:
- EISSN:
-
1745-6215
- ISSN:
-
1745-6215
- Pmid:
-
31138317
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1004606
- UUID:
-
uuid:89e5e6d8-76fa-4728-93ed-3db7d7ae96c7
- Local pid:
- pubs:1004606
- Source identifiers:
-
1004606
- Deposit date:
- 2019-06-15
Terms of use
- Copyright holder:
- Schiavone et al
- Copyright date:
- 2019
- Notes:
- © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Licence:
- CC Attribution (CC BY)
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