- Abstract:
-
A new class of DNA bisintercalators is reported in which phenanthridinium or acridinium rings are connected by rigid and extended linkers of varied length. Cross-linking of DNA by bisintercalation is inferred from the unwinding and folding of linear DNA induced by the compound; after ligation and removal of the bisintercalator, superhelical circles, catenanes, and knots that bear an imprint of the bisintercalator are observed. These novel bisintercalators are of interest because they can be u...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1021/bi00118a029
-
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- Journal:
- Biochemistry
- Volume:
- 31
- Issue:
- 3
- Pages:
- 842-849
- Publication date:
- 1992-01-05
- DOI:
- EISSN:
-
1520-4995
- ISSN:
-
0006-2960
- URN:
-
uuid:89e398c3-2b17-4a3c-8fd3-06aa7105f8a3
- Source identifiers:
-
6027
- Local pid:
- pubs:6027
- Copyright date:
- 1992
Journal article
Bisintercalators of DNA with a rigid linker in an extended configuration.
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