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Journal article

Bisintercalators of DNA with a rigid linker in an extended configuration.

Abstract:

A new class of DNA bisintercalators is reported in which phenanthridinium or acridinium rings are connected by rigid and extended linkers of varied length. Cross-linking of DNA by bisintercalation is inferred from the unwinding and folding of linear DNA induced by the compound; after ligation and removal of the bisintercalator, superhelical circles, catenanes, and knots that bear an imprint of the bisintercalator are observed. These novel bisintercalators are of interest because they can be u...

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Publication status:
Published

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Publisher copy:
10.1021/bi00118a029

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Biochemistry
Volume:
31
Issue:
3
Pages:
842-849
Publication date:
1992-01-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:89e398c3-2b17-4a3c-8fd3-06aa7105f8a3
Source identifiers:
6027
Local pid:
pubs:6027

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