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Flow-induced constriction in arterioles of hyperhomocysteinemic rats is due to impaired nitric oxide and enhanced thromboxane A(2) mediation.

Abstract:

Hyperhomocysteinemia (HHcy) is thought to promote arteriosclerosis and peripheral arterial disease, in part by impairing the function of endothelium. Because flow-induced dilation is mediated by the endothelium, we hypothesized that HHcy alters this response by interfering with the synthesis/action of NO and prostaglandins. Thus, changes in the diameter of isolated, pressurized (at 80 mm Hg) gracilis skeletal muscle arterioles (diameter approximately 170 microm) from control and methionine di...

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Publication status:
Published

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Publisher copy:
10.1161/01.atv.21.2.233

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Ungvari, Z More by this author
Szollár, L More by this author
Journal:
Arteriosclerosis, thrombosis, and vascular biology
Volume:
21
Issue:
2
Pages:
233-237
Publication date:
2001-02-05
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
URN:
uuid:89de48d7-5b93-42f5-a6a2-50bec75aaa87
Source identifiers:
164405
Local pid:
pubs:164405

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