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Vitamin D receptor gene polymorphism: association with Crohn's disease susceptibility.

Abstract:

BACKGROUND: The vitamin D receptor (VDR) gene represents a strong positional candidate susceptibility gene for inflammatory bowel disease (IBD). The VDR gene maps to a region on chromosome 12 that has been shown to be linked to IBD by genome screening techniques. It is the cellular receptor for 1,25(OH)(2) vitamin D(3) (calcitriol) which has a wide range of different regulatory effects on the immune system. IBD is characterised by activation of the mucosal immune system. AIM: To determine if ...

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Publication status:
Published

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Publisher copy:
10.1136/gut.47.2.211

Authors


Simmons, JD More by this author
Mullighan, C More by this author
Jewell, DP More by this author
Journal:
Gut
Volume:
47
Issue:
2
Pages:
211-214
Publication date:
2000-08-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:89d93c27-eeeb-441f-b524-6805ef5cf2a3
Source identifiers:
135296
Local pid:
pubs:135296

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