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The translocator protein as a marker of macrophage and stromal activation in inflammatory arthritis: An initial investigation

Abstract:

TSPO is an 18kDa mitochondrial protein of indeterminate function. Its high expression on macrophages has led to its use as an imaging marker in inflammatory disease. Due to the critical role of macrophages in arthritis pathogenesis, TSPO may be useful as a marker of disease activity in inflammatory arthritis. Here, we demonstrate the TSPO PET (positron emission tomography) tracer [11C]PBR28 can detect and quantify synovitis. Through synovial histology, we demonstrate TSPO expression in tissue...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/rheumatology/kex062.237

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Oxford college:
Wadham College
Role:
Author
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Publisher:
Oxford Academic Publisher's website
Journal:
Rheumatology 2017 Journal website
Host title:
Rheumatology 2017
Publication date:
2017-04-21
Acceptance date:
2016-10-28
DOI:
Source identifiers:
728845
Pubs id:
pubs:728845
UUID:
uuid:89d0a41f-8661-4ab2-8350-5efdbcd1527e
Local pid:
pubs:728845
Deposit date:
2018-05-21

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