Conference item icon

Conference item

The translocator protein as a marker of macrophage and stromal activation in inflammatory arthritis: An initial investigation

Abstract:

TSPO is an 18kDa mitochondrial protein of indeterminate function. Its high expression on macrophages has led to its use as an imaging marker in inflammatory disease. Due to the critical role of macrophages in arthritis pathogenesis, TSPO may be useful as a marker of disease activity in inflammatory arthritis. Here, we demonstrate the TSPO PET (positron emission tomography) tracer [11C]PBR28 can detect and quantify synovitis. Through synovial histology, we demonstrate TSPO expression in tissue...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Oxford college:
Wadham College
Role:
Author
Publisher:
Oxford Academic
Host title:
Rheumatology 2017
Journal:
Rheumatology 2017 More from this journal
Publication date:
2017-04-21
Acceptance date:
2016-10-28
DOI:
Pubs id:
pubs:728845
UUID:
uuid:89d0a41f-8661-4ab2-8350-5efdbcd1527e
Local pid:
pubs:728845
Source identifiers:
728845
Deposit date:
2018-05-21

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP