- Abstract:
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TSPO is an 18kDa mitochondrial protein of indeterminate function. Its high expression on macrophages has led to its use as an imaging marker in inflammatory disease. Due to the critical role of macrophages in arthritis pathogenesis, TSPO may be useful as a marker of disease activity in inflammatory arthritis. Here, we demonstrate the TSPO PET (positron emission tomography) tracer [11C]PBR28 can detect and quantify synovitis. Through synovial histology, we demonstrate TSPO expression in tissue...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
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(pdf, 29.9kb)
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- Publisher copy:
- 10.1093/rheumatology/kex062.237
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- Publisher:
- Oxford Academic Publisher's website
- Publication date:
- 2017-04-21
- Acceptance date:
- 2016-10-28
- DOI:
- Pubs id:
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pubs:728845
- URN:
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uri:89d0a41f-8661-4ab2-8350-5efdbcd1527e
- UUID:
-
uuid:89d0a41f-8661-4ab2-8350-5efdbcd1527e
- Local pid:
- pubs:728845
- Copyright holder:
- Taylor et al
- Copyright date:
- 2017
- Notes:
- © The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com This is the accepted manuscript version of the article. The final version is available online from Oxford University Press at: http://dx.doi.org/10.1093/rheumatology/kex062.237
Conference item
The translocator protein as a marker of macrophage and stromal activation in inflammatory arthritis: An initial investigation
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