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The translocator protein as a marker of macrophage and stromal activation in inflammatory arthritis: An initial investigation

Abstract:

TSPO is an 18kDa mitochondrial protein of indeterminate function. Its high expression on macrophages has led to its use as an imaging marker in inflammatory disease. Due to the critical role of macrophages in arthritis pathogenesis, TSPO may be useful as a marker of disease activity in inflammatory arthritis. Here, we demonstrate the TSPO PET (positron emission tomography) tracer [11C]PBR28 can detect and quantify synovitis. Through synovial histology, we demonstrate TSPO expression in tissue...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1093/rheumatology/kex062.237

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Oxford college:
Wadham College
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Publisher:
Oxford Academic Publisher's website
Publication date:
2017-04-21
Acceptance date:
2016-10-28
DOI:
Pubs id:
pubs:728845
URN:
uri:89d0a41f-8661-4ab2-8350-5efdbcd1527e
UUID:
uuid:89d0a41f-8661-4ab2-8350-5efdbcd1527e
Local pid:
pubs:728845

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