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Isolation and structure elucidation of two phosphorylated sterol sulfates, MT1-MMP inhibitors from a marine sponge Cribrochalina sp.: revision of the structures of haplosamates A and B

Abstract:

Two inhibitors of membrane-type matrix metalloproteinase (MT1-MMP) were isolated from a marine sponge Cribrochalina sp. Their structures were elucidated as unusual phosphorylated sterol sulfates by spectroscopic and chemical methods. One of the sterol sulfates was found to be identical to haplosamate A, whose structure was previously proposed to be a steroidal sulfamate ester, which led to structure revisions of both haplosamates A and B. The absolute stereochemistry of haplosamate A was dete...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
TETRAHEDRON More from this journal
Volume:
57
Issue:
18
Pages:
3885-3890
Publication date:
2001-04-30
DOI:
ISSN:
0040-4020
Language:
English
Keywords:
Pubs id:
pubs:225434
UUID:
uuid:89ccf354-7275-45cb-8dc2-1257e8024c36
Local pid:
pubs:225434
Source identifiers:
225434
Deposit date:
2012-12-19

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