- Abstract:
-
A hallmark of allergic disease is infiltration of the tissues with increased numbers of eosinophils. This is the result of the co-ordinated action of cytokines, particularly IL-5, CCR3 binding chemokines and the adhesion molecules P-selectin and VCAM-1, acting in concert to cause selective trafficking of eosinophils into allergic tissue. This process is orchestrated by the Th-2 allergen specific lymphocyte. While there is little data to support the view that eosinophils ameliorate the allergi...
Expand abstract - Publisher copy:
- 10.1258/0007142001903490
-
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- Journal:
- British medical bulletin
- Volume:
- 56
- Issue:
- 4
- Pages:
- 985-1003
- Publication date:
- 2000-01-01
- DOI:
- EISSN:
-
1471-8391
- ISSN:
-
0007-1420
- URN:
-
uuid:89b8937b-e304-4bda-a241-05a56d3b7691
- Source identifiers:
-
435362
- Local pid:
- pubs:435362
- Language:
- English
- Keywords:
- Copyright date:
- 2000
Journal article
Eosinophils in asthma and other allergic diseases.
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