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Eosinophils in asthma and other allergic diseases.

Abstract:

A hallmark of allergic disease is infiltration of the tissues with increased numbers of eosinophils. This is the result of the co-ordinated action of cytokines, particularly IL-5, CCR3 binding chemokines and the adhesion molecules P-selectin and VCAM-1, acting in concert to cause selective trafficking of eosinophils into allergic tissue. This process is orchestrated by the Th-2 allergen specific lymphocyte. While there is little data to support the view that eosinophils ameliorate the allergi...

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Publisher copy:
10.1258/0007142001903490

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Role:
Author
Journal:
British medical bulletin
Volume:
56
Issue:
4
Pages:
985-1003
Publication date:
2000-01-01
DOI:
EISSN:
1471-8391
ISSN:
0007-1420
URN:
uuid:89b8937b-e304-4bda-a241-05a56d3b7691
Source identifiers:
435362
Local pid:
pubs:435362

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