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Reduction of fibrillar strain-rate sensitivity in steroid-induced osteoporosis linked to changes in mineralized fibrillar nanostructure

Abstract:

As bone is used in a dynamic mechanical environment, understanding the structural origins of its time-dependent mechanical behaviour - and the alterations in metabolic bone disease - is of interest. However, at the scale of the mineralized fibrillar matrix (nanometre-level), the nature of the strain-rate dependent mechanics is incompletely understood. Here, we investigate the fibrillar- and mineral-deformation behaviour in a murine model of Cushing's syndrome, used to understand steroid induc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bone.2019.115111

Authors


Publisher:
Elsevier
Journal:
Bone More from this journal
Volume:
131
Article number:
115111
Publication date:
2019-11-11
Acceptance date:
2019-10-15
DOI:
EISSN:
1873-2763
ISSN:
8756-3282
Pmid:
31726107
Language:
English
Keywords:
Pubs id:
pubs:1073157
UUID:
uuid:899e39b5-ef35-4319-8255-7230476e79aa
Local pid:
pubs:1073157
Source identifiers:
1073157
Deposit date:
2020-01-10

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