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Evidence from single nucleotide polymorphism analyses of ADVANCE study demonstrates EFNB3 as a hypertension risk gene

Abstract:

EPH kinases and their ligands, ephrins (EFNs), have vital and diverse biological functions. We recently reported that Efnb3 gene deletion results in hypertension in female but not male mice. These data suggest that EFNB3 regulates blood pressure in a sex- and sex hormone-dependent way. In the present study, we conducted a human genetic study to assess the association of EFNB3 single nucleotide polymorphisms with human hypertension risks, using 3,448 patients with type 2 diabetes from the ADV...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep44114

Authors


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Name:
OPTI-THERA
Grant:
toJ.T.
P.H
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Name:
Fonds de recherche du Quebec-Santé
Grant:
Ag-06
More from this funder
Name:
Juvenile Diabetes Research Foundation
Grant:
17-2013-440
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Name:
Natural Sciences and Engineering Research Council of Canada
Grant:
203906-2012
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Name:
Canadian Institutes of Health Research
Grant:
MOP123389),H.L.(MOP97829),JT
J.W.(MOP57697,MOP69089
P.H(ISO106797
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
7
Article number:
44114
Publication date:
2017-01-01
Acceptance date:
2017-02-03
DOI:
ISSN:
2045-2322
Keywords:
Pubs id:
pubs:683951
UUID:
uuid:899aace7-9bc4-4559-a6b4-2535adf40a0f
Local pid:
pubs:683951
Source identifiers:
683951
Deposit date:
2017-03-03

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