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Evidence from single nucleotide polymorphism analyses of ADVANCE study demonstrates EFNB3 as a hypertension risk gene

Abstract:

EPH kinases and their ligands, ephrins (EFNs), have vital and diverse biological functions. We recently reported that Efnb3 gene deletion results in hypertension in female but not male mice. These data suggest that EFNB3 regulates blood pressure in a sex- and sex hormone-dependent way. In the present study, we conducted a human genetic study to assess the association of EFNB3 single nucleotide polymorphisms with human hypertension risks, using 3,448 patients with type 2 diabetes from the ADV...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/srep44114

Authors


Tremblay, J More by this author
Raelson, J More by this author
Marois-Blanchet, FC More by this author
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Grant:
J.W. (MOP57697, MOP69089 and MOP 123389), H.L. (MOP97829), JT and P.H (ISO106797)
J.-Louis Levesque Foundation More from this funder
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Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
Article: 44114
Publication date:
2017
Acceptance date:
2017-02-03
DOI:
ISSN:
2045-2322
Pubs id:
pubs:683951
URN:
uri:899aace7-9bc4-4559-a6b4-2535adf40a0f
UUID:
uuid:899aace7-9bc4-4559-a6b4-2535adf40a0f
Local pid:
pubs:683951

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