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The number needed to treat (NNT) can be adjusted for bias when the outcome is measured with error.

Abstract:

BACKGROUND AND OBJECTIVE: We consider the number needed to treat (NNT) when the event of interest is defined by dichotomizing a continuous response at a threshold level. If the response is measured with error, the resulting NNT is biased. We consider methods to reduce this bias. METHODS: Bias adjustment was studied using simulations in which we varied the distributions of the underlying response and measurement error, including both normal and nonnormal distributions. We studied a maximum li...

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Publication status:
Published

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Authors


Marschner, IC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit, BHF Centre of Research Excellence
Walter, SD More by this author
Journal:
Journal of clinical epidemiology
Volume:
57
Issue:
12
Pages:
1244-1252
Publication date:
2004-12-05
DOI:
EISSN:
1878-5921
ISSN:
0895-4356
URN:
uuid:899818fd-e1c5-49cd-a840-8083b5247bc2
Source identifiers:
164538
Local pid:
pubs:164538

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