The number needed to treat (NNT) can be adjusted for bias when the outcome is measured with error.
BACKGROUND AND OBJECTIVE: We consider the number needed to treat (NNT) when the event of interest is defined by dichotomizing a continuous response at a threshold level. If the response is measured with error, the resulting NNT is biased. We consider methods to reduce this bias. METHODS: Bias adjustment was studied using simulations in which we varied the distributions of the underlying response and measurement error, including both normal and nonnormal distributions. We studied a maximum li...Expand abstract
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