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Diabetes‐induced microvascular complications at the level of the spinal cord; a contributing factor in diabetic neuropathic pain

Abstract:

Abnormalities of neurovascular interactions within the CNS of diabetic patients is associated with the onset of many neurological disease states. However, to date, the link between the neurovascular network within the spinal cord and regulation of nociception has not been investigated despite neuropathic pain being common in diabetes. We hypothesised that hyperglycaemia‐induced endothelial degeneration in the spinal cord, due to suppression of vascular endothelial growth factor (VEGF)‐A/VEGFR...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1113/JP275067

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Rosetrees Trust More from this funder
Publisher:
John Wiley & Sons, Inc. Publisher's website
Journal:
Journal of Physiology Journal website
Volume:
596
Issue:
16
Pages:
3675-3693
Publication date:
2018-05-17
Acceptance date:
2018-05-17
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Keywords:
Pubs id:
pubs:848031
UUID:
uuid:899486b9-e1ed-4c01-8fa0-e1737a3d5066
Local pid:
pubs:848031
Source identifiers:
848031
Deposit date:
2018-07-31

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