- Abstract:
-
The purpose of this study was to investigate whether the alpha 1-adrenoceptor antagonist thymoxamine possesses antihistaminic activity in clinical doses in man, as has been reported on the guinea pig ileum in vitro. Five normal subjects were given on three separate occasions intravenous infusions of thymoxamine (0.15 mg kg-1 loading dose followed by 0.15 mg kg-1 h-1), chlorpheniramine (1.5 mg loading dose followed by 1.5 mg h-1) and normal saline (placebo). Intravenous bolus doses of histamin...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/j.1365-2125.1987.tb03142.x
-
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- Journal:
- British journal of clinical pharmacology
- Volume:
- 24
- Issue:
- 1
- Pages:
- 96-99
- Publication date:
- 1987-07-05
- DOI:
- EISSN:
-
1365-2125
- ISSN:
-
0306-5251
- URN:
-
uuid:8990a65a-c753-4d08-92f3-42873ab5a311
- Source identifiers:
-
138501
- Local pid:
- pubs:138501
- Language:
- English
- Keywords:
- Copyright date:
- 1987
Journal article
Thymoxamine: lack of antihistaminic effects in clinical doses in man.
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