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Journal article

The RSRF/MEF2 protein SL1 regulates cardiac muscle-specific transcription of a myosin light-chain gene in Xenopus embryos.

Abstract:

We have examined the role of two RSRF/MEF2 proteins in the onset of skeletal and cardiac muscle differentiation in early Xenopus embryos. In normal development, zygotic expression of SL1 (MEF2D) precedes that of SL2 (MEF2A) by several hours, but neither gene is expressed prior to the accumulation of MyoD and Myf5 transcripts in the somitic mesoderm. Ectopic expression of the myogenic factors in explants of presumptive ectoderm induces expression of both SL1 and SL2, whereas in reciprocal expe...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1101/gad.8.11.1324

Authors


Chambers, AE More by this author
Kotecha, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Publisher:
Cold Spring Harbor Laboratory Press Publisher's website
Journal:
Genes and Development Journal website
Volume:
8
Issue:
11
Pages:
1324-1334
Publication date:
1994
DOI:
ISSN:
0890-9369
URN:
uuid:899073e2-10bb-4ff0-ac4a-0ee88e61ddf8
Source identifiers:
573480
Local pid:
pubs:573480

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