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The RSRF/MEF2 protein SL1 regulates cardiac muscle-specific transcription of a myosin light-chain gene in Xenopus embryos.

Abstract:

We have examined the role of two RSRF/MEF2 proteins in the onset of skeletal and cardiac muscle differentiation in early Xenopus embryos. In normal development, zygotic expression of SL1 (MEF2D) precedes that of SL2 (MEF2A) by several hours, but neither gene is expressed prior to the accumulation of MyoD and Myf5 transcripts in the somitic mesoderm. Ectopic expression of the myogenic factors in explants of presumptive ectoderm induces expression of both SL1 and SL2, whereas in reciprocal expe...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1101/gad.8.11.1324

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Publisher:
Cold Spring Harbor Laboratory Press Publisher's website
Journal:
Genes and Development Journal website
Volume:
8
Issue:
11
Pages:
1324-1334
Publication date:
1994-01-01
DOI:
ISSN:
0890-9369
Source identifiers:
573480
Keywords:
Pubs id:
pubs:573480
UUID:
uuid:899073e2-10bb-4ff0-ac4a-0ee88e61ddf8
Local pid:
pubs:573480
Deposit date:
2015-11-16

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