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Multiple mechanisms contribute to impairment of type 1 interferon production during chronic lymphocytic choriomeningitis virus infection of mice.

Abstract:

Type 1 IFNs, innate cytokines with important effector and immunomodulatory properties, are rapidly induced in the acute phase of many virus infections; however, this is generally a transient response that is not sustained during virus persistence. To gain insight into mechanisms that can contribute to down-regulation of type 1 IFN production during virus persistence, we analyzed type 1 IFN production during acute and chronic lymphocytic choriomeningitis virus (LCMV) infection. High-level type...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.0802526

Authors


Montoya, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
182
Issue:
11
Pages:
7178-7189
Publication date:
2009-06-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:89870aaf-8386-4410-8796-d872d797ab7d
Source identifiers:
34728
Local pid:
pubs:34728

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