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Platelet c-mpl expression is dysregulated in patients with essential thrombocythaemia but this is not of diagnostic value.

Abstract:

Essential thrombocythaemia (ET) can be difficult to discriminate from an occult case of reactive thrombocytosis (RT). Since thrombopoietin (TPO) is the primary regulator of thrombopoiesis, we have investigated whether levels of TPO and/or its receptor, c-mpl, are of value in the differential diagnosis of ET. Plasma TPO levels in patients with ET, RT and other myeloproliferative disorders (MPDs) did not differ significantly from normal controls. However, surface c-mpl expression was significan...

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Journal:
British journal of haematology More from this journal
Volume:
107
Issue:
1
Pages:
139-147
Publication date:
1999-10-01
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
Language:
English
Keywords:
Pubs id:
pubs:486705
UUID:
uuid:89843b30-65d3-4430-b044-89409bb1bada
Local pid:
pubs:486705
Source identifiers:
486705
Deposit date:
2014-10-23

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