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Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study.

Abstract:

Mutations in the WNK1 gene cause Gordon's syndrome, a rare Mendelian form of hypertension. We assessed whether common WNK1 variants might also contribute to essential hypertension (EH), a multifactorial disorder affecting > 25% of the adult population worldwide. A panel of 19 single nucleotide polymorphisms (SNPs) spanning the gene was selected from public databases and was genotyped in 100 white European families to determine the pattern of linkage disequilibrium, haplotype structure and ...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddi187

Authors


Newhouse, SJ More by this author
Wallace, C More by this author
Pembroke, J More by this author
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Journal:
Human molecular genetics
Volume:
14
Issue:
13
Pages:
1805-1814
Publication date:
2005-07-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:8980acdd-47df-4011-86b2-daf9f199e82c
Source identifiers:
104859
Local pid:
pubs:104859

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