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Population genetics of the FRAXE and FRAXF GCC repeats, and a novel CGG repeat, in Xq28.

Abstract:

Most of the rare folate sensitive fragile sites cloned to date arise from expansion of a CGG:CCG trinucleotide repeat array. Analysis of the CAG repeat at the Huntington Disease (HD) locus showed a positively skewed repeat distribution leading to the proposal that microsatellites are subject to a mutational bias toward expansion. Such a mutational bias predicts an increase in mean repeat size at all microsatellite loci. We present an analysis of repeats at two fragile site loci, FRAXE and FRA...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
Journal:
American journal of medical genetics
Volume:
73
Issue:
4
Pages:
463-469
Publication date:
1997-12-05
DOI:
EISSN:
1096-8628
ISSN:
0148-7299
URN:
uuid:8979f6fc-4766-42e2-8291-38e2b8bcf7d3
Source identifiers:
36132
Local pid:
pubs:36132

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