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Population genetics of the FRAXE and FRAXF GCC repeats, and a novel CGG repeat, in Xq28.

Abstract:

Most of the rare folate sensitive fragile sites cloned to date arise from expansion of a CGG:CCG trinucleotide repeat array. Analysis of the CAG repeat at the Huntington Disease (HD) locus showed a positively skewed repeat distribution leading to the proposal that microsatellites are subject to a mutational bias toward expansion. Such a mutational bias predicts an increase in mean repeat size at all microsatellite loci. We present an analysis of repeats at two fragile site loci, FRAXE and FRA...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
American journal of medical genetics
Volume:
73
Issue:
4
Pages:
463-469
Publication date:
1997-12-01
DOI:
EISSN:
1096-8628
ISSN:
0148-7299
Source identifiers:
36132
Language:
English
Keywords:
Pubs id:
pubs:36132
UUID:
uuid:8979f6fc-4766-42e2-8291-38e2b8bcf7d3
Local pid:
pubs:36132
Deposit date:
2013-02-20

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