- Abstract:
-
The oncogenic phosphatase of regenerating liver 2 (PRL-2) has been shown to regulate intracellular magnesium levels by forming a complex through an extended amino acid loop present in the Bateman module of the CNNM3 magnesium transporter. Here we identified highly conserved residues located on this amino acid loop critical for the binding with PRL-2. A single point mutation (D426A) of one of those critical amino acids was found to completely disrupt PRL-2·human Cyclin M 3 (CNNM3) complex form...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.9MB)
-
- Publisher copy:
- 10.1074/jbc.M115.705863
-
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- Publisher:
- American Society for Biochemistry and Molecular Biology Publisher's website
- Journal:
- The Journal of Biological Chemistry Journal website
- Volume:
- 291
- Issue:
- 20
- Pages:
- 10716-10725
- Publication date:
- 2016-03-11
- Acceptance date:
- 2016-02-24
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:89724605-7e98-4a15-8cd0-7ed99d2976bd
- Source identifiers:
-
633123
- Local pid:
- pubs:633123
- Paper number:
- 20
- Language:
- English
- Keywords:
- Copyright holder:
- The American Society for Biochemistry and Molecular Biology, Inc.
- Copyright date:
- 2016
- Notes:
- This article is distributed under the terms of a Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/).
- License:
- https://creativecommons.org/licenses/by/4.0/
Journal article
Inhibition of PRL-2·CNNM3 protein complex formation decreases breast cancer proliferation and tumor growth
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