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Journal article

Inhibition of PRL-2·CNNM3 protein complex formation decreases breast cancer proliferation and tumor growth

Abstract:

The oncogenic phosphatase of regenerating liver 2 (PRL-2) has been shown to regulate intracellular magnesium levels by forming a complex through an extended amino acid loop present in the Bateman module of the CNNM3 magnesium transporter. Here we identified highly conserved residues located on this amino acid loop critical for the binding with PRL-2. A single point mutation (D426A) of one of those critical amino acids was found to completely disrupt PRL-2·human Cyclin M 3 (CNNM3) complex form...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1074/jbc.M115.705863

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
The Journal of Biological Chemistry Journal website
Volume:
291
Issue:
20
Pages:
10716-10725
Publication date:
2016-03-11
Acceptance date:
2016-02-24
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:89724605-7e98-4a15-8cd0-7ed99d2976bd
Source identifiers:
633123
Local pid:
pubs:633123
Paper number:
20

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