Journal article
Inhibition of PRL-2·CNNM3 protein complex formation decreases breast cancer proliferation and tumor growth
- Abstract:
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The oncogenic phosphatase of regenerating liver 2 (PRL-2) has been shown to regulate intracellular magnesium levels by forming a complex through an extended amino acid loop present in the Bateman module of the CNNM3 magnesium transporter. Here we identified highly conserved residues located on this amino acid loop critical for the binding with PRL-2. A single point mutation (D426A) of one of those critical amino acids was found to completely disrupt PRL-2·human Cyclin M 3 (CNNM3) complex form...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.9MB)
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- Publisher copy:
- 10.1074/jbc.M115.705863
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Authors
Bibliographic Details
- Publisher:
- American Society for Biochemistry and Molecular Biology Publisher's website
- Journal:
- Journal of Biological Chemistry Journal website
- Volume:
- 291
- Issue:
- 20
- Pages:
- 10716-10725
- Publication date:
- 2016-03-11
- Acceptance date:
- 2016-02-24
- DOI:
- EISSN:
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1083-351X
- ISSN:
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0021-9258
- Source identifiers:
-
633123
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:633123
- UUID:
-
uuid:89724605-7e98-4a15-8cd0-7ed99d2976bd
- Local pid:
- pubs:633123
- Deposit date:
- 2016-07-12
Terms of use
- Copyright holder:
- The American Society for Biochemistry and Molecular Biology, Inc
- Copyright date:
- 2016
- Notes:
- This article is distributed under the terms of a Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/).
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