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Virus-specific CTL responses induced by an H-2Kd-restricted, motif-negative 15-mer peptide from the fusion protein of respiratory syncytial virus

Abstract:

We describe 15-mer peptide P8:F92-106 from the F protein of respiratory syncytial virus (RSV) that can act as an MHC class I-restricted (H-2K(d)) epitope for RSV-specific CD8(+) CTL. This peptide is interesting because not only is it the first murine CTL epitope to be identified in the F protein but also because it does not contain a known allele-specific motif, as all 15 amino acids appear to be required for effective presentation to CTL. In in vitro MHC class I refolding experiments, peptid...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1099/0022-1317-83-2-429

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Name:
Mary Kinross Charitable Trust
Publisher:
Microbiology Society
Journal:
Journal of General Virology More from this journal
Volume:
83
Issue:
2
Pages:
429-438
Publication date:
2002-02-01
Acceptance date:
2001-10-15
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
Pmid:
11807236

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