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Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens

Abstract:

Background: In humans and other animals, the chronic hypoxic response is mediated by hypoxia inducible transcription factors (HIFs) which regulate the expression of genes that counteract the effects of limiting oxygen. Prolyl hydroxylases (PHDs) act as hypoxia sensors for the HIF system in organisms ranging from humans to the simplest animal Trichoplax adhaerens.

Methods: We report structural and biochemical studies on the T. adhaerens HIF prolyl hy...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2147/HP.S174655

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
ORCID:
0000-0003-2141-5988
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
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Leverhulme Trust More from this funder
National Institutes of Health More from this funder
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Publisher:
Dove Medical Press Publisher's website
Journal:
Hypoxia Journal website
Volume:
2018
Issue:
6
Pages:
57—71
Publication date:
2018-11-09
Acceptance date:
2018-07-27
DOI:
ISSN:
2324-1128
Keywords:
Pubs id:
pubs:915989
UUID:
uuid:897158b3-6c1e-4c70-aef4-a1deb6b38df1
Local pid:
pubs:915989
Deposit date:
2018-09-09

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