Journal article
Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens
- Abstract:
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Background: In humans and other animals, the chronic hypoxic response is mediated by hypoxia inducible transcription factors (HIFs) which regulate the expression of genes that counteract the effects of limiting oxygen. Prolyl hydroxylases (PHDs) act as hypoxia sensors for the HIF system in organisms ranging from humans to the simplest animal Trichoplax adhaerens.
Methods: We report structural and biochemical studies on the T. adhaerens HIF prolyl hy...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 4.5MB)
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- Publisher copy:
- 10.2147/HP.S174655
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Authors
Funding
Leverhulme Trust
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National Institutes of Health
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Bibliographic Details
- Publisher:
- Dove Medical Press Publisher's website
- Journal:
- Hypoxia Journal website
- Volume:
- 2018
- Issue:
- 6
- Pages:
- 57—71
- Publication date:
- 2018-11-09
- Acceptance date:
- 2018-07-27
- DOI:
- ISSN:
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2324-1128
Item Description
- Keywords:
- Pubs id:
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pubs:915989
- UUID:
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uuid:897158b3-6c1e-4c70-aef4-a1deb6b38df1
- Local pid:
- pubs:915989
- Deposit date:
- 2018-09-09
Terms of use
- Copyright holder:
- Lippl et al
- Copyright date:
- 2018
- Notes:
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© 2018 Lippl et al.
This work is published by Dove Medical Press Limited, and licensed under a Creative Commons Attribution License. The license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
- Licence:
- CC Attribution (CC BY)
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