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Journal article

Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites.

Abstract:

Background

Malaria parasites have evolved a series of intricate mechanisms to survive and propagate within host red blood cells. Intra-erythrocytic parasitism requires these organisms to digest haemoglobin and detoxify ironbound haem. These tasks are executed by haemoglobin-specific proteases and haem biocrystallization factors that are components of a large multi-subunit complex. Since haemoglobin processing machineries are functionally and genetically linked to the modes of acti...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12936-016-1097-9

Authors


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Grand Challenges Canada More from this funder
Office of the Higher Education Commission More from this funder
Mahidol University More from this funder
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Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal Journal website
Volume:
15
Issue:
1
Pages:
51
Chapter number:
ARTN 51
Publication date:
2016-01-05
DOI:
EISSN:
1475-2875
ISSN:
1475-2875
URN:
uuid:896ed9ca-552b-4817-81f8-1f27d39deea4
Source identifiers:
601492
Local pid:
pubs:601492
Language:
English

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