The pathogenesis of the bone disease of multiple myeloma.

Journal article

Multiple myeloma is a fatal hematologic malignancy associated with clonal expansion of malignant plasma cells within the bone marrow and the development of a destructive osteolytic bone disease. The principal cellular mechanisms involved in the development of myeloma bone disease are an increase in osteoclastic bone resorption, and a reduction in bone formation. Myeloma cells are found in close association with sites of active bone resorption, and the interactions between myeloma cells and ot...

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Authors: Edwards, C; Zhuang, J; Mundy, G

• Publication status: Published
• Journal: Bone
• Volume: 42
• Issue: 6
• Pages: 1007-1013
• Publication date: 2008-06-01
• DOI: 10.1016/j.bone.2008.01.027
• EISSN: 1873-2763
• ISSN: 8756-3282
• Language: English
• Keywords: Bone Marrow Cells; Humans; Osteoblasts; Bone Resorption; Bone and Bones; Multiple Myeloma; Animals; Osteogenesis; Cytokines; Osteoclasts; Chemokines