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Journal article

Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump.

Abstract:

Multidrug resistance is a serious barrier to successful treatment of many human diseases, including cancer, wherein chemotherapeutics are exported from target cells by membrane-embedded pumps. The most prevalent of these pumps, the ATP-Binding Cassette transporter P-glycoprotein (P-gp), consists of two homologous halves each comprising one nucleotide-binding domain and six transmembrane helices. The transmembrane region encapsulates a hydrophobic cavity, accessed by portals in the membrane, t...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1303888110

Authors


Marcoux, J More by this author
Politis, A More by this author
Reading, E More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
110
Issue:
24
Pages:
9704-9709
Publication date:
2013-06-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:896bcb08-4a4b-467f-a1bc-0cb71e14d534
Source identifiers:
401273
Local pid:
pubs:401273

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