- Abstract:
-
Multidrug resistance is a serious barrier to successful treatment of many human diseases, including cancer, wherein chemotherapeutics are exported from target cells by membrane-embedded pumps. The most prevalent of these pumps, the ATP-Binding Cassette transporter P-glycoprotein (P-gp), consists of two homologous halves each comprising one nucleotide-binding domain and six transmembrane helices. The transmembrane region encapsulates a hydrophobic cavity, accessed by portals in the membrane, t...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.1303888110
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 110
- Issue:
- 24
- Pages:
- 9704-9709
- Publication date:
- 2013-06-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:896bcb08-4a4b-467f-a1bc-0cb71e14d534
- Source identifiers:
-
401273
- Local pid:
- pubs:401273
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump.
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