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Classifying the antibody-negative NMO syndromes: Clinical, imaging, and metabolomic modeling

Abstract:

Objective To determine whether unsupervised principal component analysis (PCA) of comprehensive clinico-radiologic data can identify phenotypic subgroups within antibody-negative patients with overlapping features of multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSDs), and to validate the phenotypic classifications using high-resolution nuclear magnetic resonance (NMR) plasma metabolomics with inference to underlying pathologies. Methods Forty-one antibody-negative p...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1212/nxi.0000000000000626

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Division:
MSD
Sub department:
Pharmacology
Role:
Author
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Publisher:
Lippincott, Williams & Wilkins (LWW) Publisher's website
Journal:
Neurology, Neuroimmunology and Neuroinflammation Journal website
Volume:
6
Issue:
6
Article number:
e626
Place of publication:
United States
Publication date:
2019-10-28
Acceptance date:
2019-08-13
DOI:
EISSN:
2332-7812
Pmid:
31659123
Language:
English
Keywords:
Pubs id:
1068768
Local pid:
pubs:1068768
Deposit date:
2020-05-27

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