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Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway.

Abstract:

We tested the hypothesis that natriuretic peptide receptors (NPRs) that are coupled to cGMP production act in a similar way to nitric oxide (NO) by enhancing acetylcholine release and vagal-induced bradycardia. The effects of enzyme inhibitors and channel blockers on the action of atrial natriuretic peptide (ANP), brain-derived natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) were evaluated in isolated guinea pig atrial-right vagal nerve preparations. RT-PCR confirmed the prese...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD
Paterson, DJ More by this author
Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
281
Issue:
6
Pages:
H2318-H2327
Publication date:
2001-12-05
EISSN:
1522-1539
ISSN:
0363-6135
URN:
uuid:89696b3c-c9f0-48e1-baa1-c52d342d37e0
Source identifiers:
105328
Local pid:
pubs:105328

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