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A radioimmuno-precipitation assay for antibodies to botulinum A.

Abstract:

We quantified antibodies to botulinum A (anti-BTx) by immunoprecipitation of 125I-BTx. We tested seven bioassay-positive sera and 68 coded samples, including 18 from patients who had ceased to respond to BTx treatment. Compared with values from healthy control subjects and 42 neurologic control subjects, all bioassay-positive sera were positive (range, 258 to 2,809 pM) and 49 of 50 patients who continued to respond to BTx were negative (<130 pM). This simple, specific, sensitive, and quant...

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Publication status:
Published

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Publisher copy:
10.1212/wnl.50.5.1463

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
Neurology
Volume:
50
Issue:
5
Pages:
1463-1466
Publication date:
1998-05-05
DOI:
EISSN:
1526-632X
ISSN:
0028-3878
URN:
uuid:8962a282-cde9-4a77-9943-9793e6f8f14a
Source identifiers:
387052
Local pid:
pubs:387052

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