- Abstract:
-
Disparate enveloped viruses initiate infection by fusing with endosomes. However, the highly diverse and dynamic nature of endosomes impairs mechanistic studies of fusion and identification of sub-cellular sites supporting the nucleocapsid release. We took advantage of the extreme stability of avian retrovirus-receptor complexes at neutral pH and of acid-dependence of virus-endosome fusion to isolate the latter step from preceding asynchronous internalization/trafficking steps. Viruses were t...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 5.4mb)
-
- Publisher copy:
- 10.1371/journal.ppat.1002694
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS pathogens Journal website
- Volume:
- 8
- Issue:
- 5
- Pages:
- e1002694
- Publication date:
- 2012
- DOI:
- EISSN:
-
1553-7374
- ISSN:
-
1553-7366
- URN:
-
uuid:8962997b-962d-43a6-970c-d4b99ddbeca9
- Source identifiers:
-
394786
- Local pid:
- pubs:394786
- Copyright holder:
- Padilla-Parra et al.
- Copyright date:
- 2012
- Notes:
- © 2012 Padilla-Parra et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Synchronized retrovirus fusion in cells expressing alternative receptor isoforms releases the viral core into distinct sub-cellular compartments.
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