Journal article
Synchronized retrovirus fusion in cells expressing alternative receptor isoforms releases the viral core into distinct sub-cellular compartments.
- Abstract:
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Disparate enveloped viruses initiate infection by fusing with endosomes. However, the highly diverse and dynamic nature of endosomes impairs mechanistic studies of fusion and identification of sub-cellular sites supporting the nucleocapsid release. We took advantage of the extreme stability of avian retrovirus-receptor complexes at neutral pH and of acid-dependence of virus-endosome fusion to isolate the latter step from preceding asynchronous internalization/trafficking steps. Viruses were t...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 5.4MB)
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- Publisher copy:
- 10.1371/journal.ppat.1002694
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Authors
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS pathogens Journal website
- Volume:
- 8
- Issue:
- 5
- Pages:
- e1002694
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
-
1553-7374
- ISSN:
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1553-7366
- Source identifiers:
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394786
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:8962997b-962d-43a6-970c-d4b99ddbeca9
- Local pid:
- pubs:394786
- Deposit date:
- 2013-11-16
Terms of use
- Copyright holder:
- Padilla-Parra et al
- Copyright date:
- 2012
- Notes:
- © 2012 Padilla-Parra et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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