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Synchronized retrovirus fusion in cells expressing alternative receptor isoforms releases the viral core into distinct sub-cellular compartments.

Abstract:

Disparate enveloped viruses initiate infection by fusing with endosomes. However, the highly diverse and dynamic nature of endosomes impairs mechanistic studies of fusion and identification of sub-cellular sites supporting the nucleocapsid release. We took advantage of the extreme stability of avian retrovirus-receptor complexes at neutral pH and of acid-dependence of virus-endosome fusion to isolate the latter step from preceding asynchronous internalization/trafficking steps. Viruses were t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1002694

Authors


Padilla-Parra, S More by this author
Melikyan, GB More by this author
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
8
Issue:
5
Pages:
e1002694
Publication date:
2012
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:8962997b-962d-43a6-970c-d4b99ddbeca9
Source identifiers:
394786
Local pid:
pubs:394786

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