Journal article
Hodgkin–Huxley revisited: reparametrization and identifiability analysis of the classic action potential model with approximate Bayesian methods
- Abstract:
-
As cardiac cell models become increasingly complex, a correspondingly complex ‘genealogy’ of inherited parameter values has also emerged. The result has been the loss of a direct link between model parameters and experimental data, limiting both reproducibility and the ability to re-fit to new data. We examine the ability of approximate Bayesian computation (ABC) to infer parameter distributions in the seminal action potential model of Hodgkin and Huxley, for which an immediate and documented...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ Engineering and Physical Sciences Research Council
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Grant:
EP/K014463/1
EP/I017909/1
Bibliographic Details
- Publisher:
- Royal Society Publisher's website
- Journal:
- Royal Society Open Science Journal website
- Volume:
- 2
- Issue:
- 12
- Pages:
- Article number: 150499
- Publication date:
- 2015-12-01
- Acceptance date:
- 2015-11-17
- DOI:
- EISSN:
-
2054-5703
- Pmid:
-
27019736
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:574341
- UUID:
-
uuid:8961e55b-c528-446c-8979-7614de486858
- Local pid:
- pubs:574341
- Source identifiers:
-
574341
- Deposit date:
- 2018-04-04
Terms of use
- Copyright holder:
- Daly et al
- Copyright date:
- 2015
- Notes:
- © 2015 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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