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The pharmacokinetic properties of intramuscular quinine in Gambian children with severe falciparum malaria.

Abstract:

Plasma quinine concentrations were measured in 21 Gambian children with severe falciparum malaria after intramuscular administration of a 20 mg (salt) per kg loading dose of quinine dihydrochloride followed by 10 mg/kg at 12 h intervals. Quinine was well absorbed reaching mean peak concentrations of 15.6 (standard deviation [SD] 4.5) mg/litre in a median time of 3 h (range 1-6 h). A one compartment model was fitted to the plasma concentration-time profile. The mean estimated systemic clearanc...

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Publication status:
Published

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Authors


Krishna, S More by this author
Craddock, C More by this author
Brewster, D More by this author
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Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume:
84
Issue:
4
Pages:
488-491
Publication date:
1990
DOI:
EISSN:
1878-3503
ISSN:
0035-9203
URN:
uuid:895cb25e-d940-4116-b3bd-4b850e103eb5
Source identifiers:
35085
Local pid:
pubs:35085

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