Journal article
The pharmacokinetic properties of intramuscular quinine in Gambian children with severe falciparum malaria.
- Abstract:
-
Plasma quinine concentrations were measured in 21 Gambian children with severe falciparum malaria after intramuscular administration of a 20 mg (salt) per kg loading dose of quinine dihydrochloride followed by 10 mg/kg at 12 h intervals. Quinine was well absorbed reaching mean peak concentrations of 15.6 (standard deviation [SD] 4.5) mg/litre in a median time of 3 h (range 1-6 h). A one compartment model was fitted to the plasma concentration-time profile. The mean estimated systemic clearanc...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/0035-9203(90)90009-4
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Bibliographic Details
- Journal:
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Volume:
- 84
- Issue:
- 4
- Pages:
- 488-491
- Publication date:
- 1990-01-01
- DOI:
- EISSN:
-
1878-3503
- ISSN:
-
0035-9203
- Source identifiers:
-
35085
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:35085
- UUID:
-
uuid:895cb25e-d940-4116-b3bd-4b850e103eb5
- Local pid:
- pubs:35085
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1990
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