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The structure of the HIV-1 Vpu ion channel: modelling and simulation studies.

Abstract:

Vpu is an 81 amino acid auxiliary protein in HIV-1 which exhibits channel activity. We used two homo-pentameric bundles with the helical transmembrane segments derived from FTIR spectroscopy in combination with a global molecular dynamics search protocol: (i) tryptophans (W) pointing into the pore, and (ii) W facing the lipids. Two equivalent bundles have been generated using a simulated annealing via a restrained molecular dynamics simulations (SA/MD) protocol. A fifth model was generated vi...

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Publication status:
Published

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Authors


Cordes, FS More by this author
Forrest, LR More by this author
Sansom, MS More by this author
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Journal:
Biochimica et biophysica acta
Volume:
1512
Issue:
2
Pages:
291-298
Publication date:
2001-06-05
DOI:
ISSN:
0006-3002
URN:
uuid:89525138-cb30-4a9c-a37f-01ca02233156
Source identifiers:
100855
Local pid:
pubs:100855

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