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Agrin is required for survival and function of monocytic cells.

Abstract:

Agrin, an extracellular matrix protein belonging to the heterogeneous family of heparan sulfate proteoglycans (HSPGs), is expressed by cells of the hematopoietic system but its role in leukocyte biology is not yet clear. Here we demonstrate that agrin has a crucial, nonredundant role in myeloid cell development and functions. We have identified lineage-specific alterations that affect maturation, survival and properties of agrin-deficient monocytic cells, and occur at stages later than stem c...

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Journal:
Blood
Volume:
119
Issue:
23
Pages:
5502-5511
Publication date:
2012-06-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:8951bb49-6138-447a-aae1-a2f48956eeae
Source identifiers:
426248
Local pid:
pubs:426248

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