Journal article
Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study.
- Abstract:
-
INTRODUCTION: Levels of cerebrospinal fluid (CSF) β-amyloid (Aβ) and Tau proteins change in Alzheimer's disease (AD). We tested if the relationships of these biomarkers with cognitive impairment are linear or non-linear. METHODS: We assessed cognitive function and assayed CSF Aβ and Tau biomarkers in 95 non-demented volunteers and 97 AD patients. We then tested non-linearities in their inter-relations. RESULTS: CSF biomarkers related to cognitive function in the non-demented range of cogniti...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ NIHR Oxford Biomedical Research Centre
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Funding agency for:
Williams, J
Wilcock, G
Merck and Co Inc
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Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- Alzheimer's Research and Therapy Journal website
- Volume:
- 3
- Issue:
- 1
- Article number:
- 5
- Publication date:
- 2011-01-01
- DOI:
- EISSN:
-
1758-9193
- ISSN:
-
1758-9193
Item Description
- Language:
- English
- Pubs id:
-
pubs:127145
- UUID:
-
uuid:89509b70-2685-4ec4-afb2-9e3a38c9d6b8
- Local pid:
- pubs:127145
- Source identifiers:
-
127145
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Williams et al
- Copyright date:
- 2011
- Notes:
- © 2011 Williams et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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