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Selection of T cell clones expressing high-affinity public TCRs within Human cytomegalovirus-specific CD8 T cell responses.

Abstract:

Assessment of clonal diversity of T cell responses against human CMV (HCMV), a major cause of morbidity in immunodepressed patients, provides important insights into the molecular basis of T cell immunodominance, and has also clinical implications for the immunomonitoring and immunotherapy of HCMV infections. We performed an in-depth molecular and functional characterization of CD8 T cells directed against an immunodominant HLA-A2-restricted epitope derived from HCMV protein pp65 (NLV/A2) in ...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.175.9.6123

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Journal:
Journal of Immunology More from this journal
Volume:
175
Issue:
9
Pages:
6123-6132
Publication date:
2005-11-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Language:
English
Keywords:
Pubs id:
pubs:33274
UUID:
uuid:89507bbc-a8b6-4e90-997c-c8c474df01e1
Local pid:
pubs:33274
Source identifiers:
33274
Deposit date:
2012-12-19

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