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A mouse-to-man candidate gene study identifies association of chronic otitis media with the loci TGIF1 and FBXO11.

Abstract:

Chronic otitis media with effusion (COME) is the most common cause of hearing loss in children, and known to have high heritability. Mutant mouse models have identified Fbxo11, Evi1, Tgif1, and Nisch as potential risk loci. We recruited children aged 10 and under undergoing surgical treatment for COME from 35 hospitals in the UK, and their nuclear family. We performed association testing with the loci FBXO11, EVI1, TGIF1 and NISCH and sought to replicate significant results in a case-control ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
ORCID:
0000-0003-2307-4021
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Name:
Medical Research Council
Grant:
MC_U142684175
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Name:
League of Friends of Oxford University Hospitals
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Name:
National Institute for Health Research
Publisher:
Nature Publishing Group
Journal:
Scientific Reports More from this journal
Volume:
7
Issue:
1
Pages:
12496
Publication date:
2017-10-01
Acceptance date:
2017-09-15
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pmid:
28970529
Language:
English
Keywords:
Pubs id:
pubs:732920
UUID:
uuid:894da928-7e78-4743-8b99-3ead6c17dd6a
Local pid:
pubs:732920
Source identifiers:
732920
Deposit date:
2018-01-05

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