Journal article
Low-frequency and rare-coding variation contributes to multiple sclerosis risk
- Abstract:
-
Multiple sclerosis is a complex neurological disease, with ∼20% of risk heritability attributable to common genetic variants, including >230 identified by genome-wide association studies. Multiple strands of evidence suggest that much of the remaining heritability is also due to additive effects of common variants rather than epistasis between these variants or mutations exclusive to individual families. Here, we show in 68,379 cases and controls that up to 5% of this heritability is expla...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell Journal website
- Volume:
- 175
- Issue:
- 6
- Pages:
- 1679-1687.e7
- Publication date:
- 2018-10-18
- Acceptance date:
- 2018-09-24
- DOI:
- EISSN:
-
1097-4172
- ISSN:
-
0092-8674
- Pmid:
-
30343897
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:960122
- UUID:
-
uuid:894966b5-204b-4eba-9d5f-33ed383d017d
- Local pid:
- pubs:960122
- Source identifiers:
-
960122
- Deposit date:
- 2019-03-20
Terms of use
- Copyright holder:
- International Multiple Sclerosis Genetics Consortium
- Copyright date:
- 2018
- Notes:
- © 2018 The Author. Published by Elsevier Inc. This is an open access article under the CC BY license
- Licence:
- CC Attribution (CC BY)
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