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Structural and mechanistic studies on prolyl hydroxylases

Abstract:

Oxygen dependent prolyl-4-hydroxylation of the alpha-subunit of the hypoxia inducible transcription factor (HIF-alpha) plays an essential role in the hypoxic response. Hydroxylation of proline residues in the N- or C-terminal oxygen dependent degradation domains (NODD or CODD) increases the affinity of HIF-alpha to the von Hippel-Lindau protein (pVHL) by approx. 1000 fold so signalling for HIF-alpha degradation. With limiting oxygen, HIF-alpha hydroxylation slows, it dimerises with HIF-bet...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Hertford College
Role:
Author

Contributors

Division:
MPLS
Department:
Chemistry
Role:
Supervisor
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Name:
Commonwealth Scholarship Commission
Funding agency for:
Chowdhury, R
Publication date:
2008
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK

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